THE STACK — EVERY INGREDIENT. EVERY
REASON.
Riboflavin (Vitamin B2) — 1mg
Riboflavin is the master regulator of mitochondrial Complex I and Complex II in the electron transport chain — the very first step in ATP synthesis. Without adequate B2, the entire energy cascade stalls upstream of everything else in this formula. It also regenerates
glutathione, your primary intracellular antioxidant, keeping oxidative damage in check as NAD+ metabolism accelerates.
Vitamin B6 — 5mg
B6 is involved in over 100 enzymatic reactions with a specific and critical role in NAD+ biosynthesis via the de novo tryptophan pathway. It is also essential for neurotransmitter synthesis — serotonin, dopamine, GABA — meaning its absence is felt cognitively long before
any bloodwork flags a deficiency. Included here as a cofactor to support the full NAD+ production cascade that the rest of this formula depends on.
Vitamin B12 — 250mcg
B12 is required for DNA synthesis, myelin sheath maintenance, and the methylation cycle that keeps homocysteine levels in check. It works synergistically with TMG — also in this formula — to ensure the methylation demands created by elevated NAD+ metabolism are
fully supported. Elevated homocysteine is one of the most reliable independent predictors of cardiovascular and neurodegenerative decline. B12 keeps it controlled.
NMN — Nicotinamide Mononucleotide — 250mg | Liposomal 84% vs 25%
standard
NAD+ is the fuel your mitochondria run on. After 40, your levels drop by up to 50%. NMN is one enzymatic step from NAD+ — the most direct precursor in the human biosynthesis pathway. A dedicated intestinal transporter called Slc12a8 facilitates direct NMN absorption
and becomes increasingly active with age, suggesting the body itself identifies NMN replenishment as a longevity priority. More NAD+ means more ATP, activated sirtuins, and active DNA repair.
NR — Nicotinamide Riboside — 250mg | Liposomal 85% vs 30% standard
Where NMN dominates metabolic and gut tissue, NR's smaller molecular size gives it superior uptake in neurological tissue via nucleoside transporters most active in the brain and nervous system. Backed by over 40 completed clinical trials and FDA GRAS status, NR is
the most extensively researched NAD+ precursor in existence. NMN and NR together cover every tissue type. Either alone leaves gaps. Immortal runs both.
NAD+ — 250mg | Liposomal 65% vs 5% standard
NAD+ cannot cross cell membranes unassisted — making direct supplementation in standard form essentially futile. Liposomal encapsulation bypasses that barrier completely. Inside the cell it immediately fuels the electron transport chain, drives ATP synthesis, and
activates the sirtuin family of longevity enzymes. NMN and NR build NAD+ endogenously.
Immortal also delivers it directly. Both pathways firing simultaneously.
Quercetin
Quercetin is a flavonoid senolytic — targeting and clearing senescent "zombie" cells that accumulate with age and release inflammatory signals that accelerate degeneration in surrounding healthy tissue. It acts as a shield against free radicals, combats chronic low-grade inflammation linked to age-related disease, and supports cardiovascular and immune function. Most effective when paired with fisetin — both are in this formula.
Trans-Resveratrol | Liposomal 90% vs 1% standard
Resveratrol activates SIRT1 — the master longevity sirtuin — which drives PGC-1α, the primary regulator of mitochondrial biogenesis. More mitochondria. Better mitochondria. Greater ATP output per cell. Sirtuins require NAD+ as a cofactor, meaning the NMN/NR/NAD+ stack and resveratrol amplify each other directly and measurably. At 1% standard bioavailability, resveratrol is one of the most wasted ingredients in the supplement industry. At 90% liposomal, it is one of the most powerful.
Fisetin
Fisetin is a potent senolytic and SIRT1 activator found naturally in strawberries. It targets and clears senescent cells, crosses the blood-brain barrier for direct neuroprotection, inhibits the PI3K/mTOR ageing signalling pathway, and has demonstrated lifespan extension in
animal models. David Sinclair takes 500mg daily. Immortal delivers it liposomal. Paired with quercetin, its senolytic effect is amplified.
EGCG — Epigallocatechin Gallate
The most bioactive catechin in green tea and one of the most studied polyphenols in longevity research. EGCG activates AMPK — the cellular energy sensor that triggers mitochondrial repair, fat oxidation, and autophagy. It inhibits mTOR, the pathway associated with accelerated cellular ageing when chronically overactive. It also supports telomere integrity, reduces inflammatory cytokine production, and crosses the blood-brain barrier for direct neuroprotection.
L-Theanine
L-Theanine is the amino acid responsible for the calm focus of green tea. In the context of a longevity stack, it plays a specific role: it reduces cortisol-driven neuroinflammation, supports GABA and dopamine synthesis, and promotes alpha brain wave activity.
Chronically elevated cortisol accelerates cellular ageing via telomere attrition and mitochondrial dysfunction. L-Theanine is the stack's stress-axis modulator — often overlooked, always essential.
Astragalus
Astragalus contains cycloastragenol — one of the only compounds in existence demonstrated to activate telomerase, the enzyme that extends and repairs telomere length. Telomere attrition is one of the nine recognised hallmarks of ageing. In a double-blind clinical trial,
astragalus extract increased average telomere length and reduced the percentage of critically short telomeres. Astragalus is the only compound in Immortal — and one of very few in existence — that directly addresses this hallmark.
TMG — Trimethylglycine
TMG is the methylation insurance policy for the entire formula. When NMN raises NAD+ levels, it increases the body's demand on methyl group supply. TMG donates methyl groups to prevent this drain — ensuring elevated NAD+ metabolism doesn't deplete the methylation
reserves critical for DNA repair, gene expression regulation, and homocysteine conversion.
David Sinclair includes TMG specifically because of NMN. Immortal does the same.
Piperine
Black pepper extract standardised for piperine. Its function is precise: it inhibits the liver enzymes and intestinal transporters responsible for first-pass clearance of polyphenols and flavonoids. Piperine increases the absorption of resveratrol, quercetin, fisetin, and EGCG by
documented multiples. In a liposomal formula already operating at elevated bioavailability, piperine compounds the effect of every other compound in the stack.
Spermidine
Spermidine is a polyamine found in every cell whose concentration decreases with age. It is the most studied caloric restriction mimetic — inducing autophagy (cellular housekeeping) through the same biochemical pathway as fasting, without fasting. It maintains mitochondrial function, reduces inflammation, protects stem cells from ageing, and has been linked to improved memory performance and reduced telomere attrition in human studies.
Oral bioavailability of standard spermidine is poor. Liposomal encapsulation addresses this directly.
GHK-CU — THE COMPOUND THAT SEPARATES IMMORTAL
Copper Tripeptide (Glycyl-L-Histidyl-L-Lysine) · 2.5mg Liposomal
You will not find GHK-Cu liposomal in a capsule-format longevity supplement anywhere else on the market. This is the compound the Mad Scientist built the formula around.
At age 20 your plasma GHK-Cu is 200 ng/ml. By age 60 it has dropped to 80 ng/ml. That 60% decline is not coincidence. It is mechanism.
GHK-Cu is a naturally occurring copper-binding tripeptide first isolated from human plasma in 1973. Almost five decades of research have established what it does at the genetic level — and the findings are extraordinary.
GENE REPROGRAMMING
GHK-Cu modulates the expression of over 4,000 human genes — silencing inflammatory and ageing-related genes while activating DNA repair, antioxidant defense, collagen synthesis, and tissue regeneration pathways. Age-related changes in gene expression that were once considered permanent have been demonstrated to be reversible.
