WHAT IS NAD+?
Nicotinamide Adenine Dinucleotide. It is not a supplement trend. It is the primary coenzyme in every mitochondrial energy-producing reaction in the human body. Without NAD+, your cells cannot complete oxidative phosphorylation — the process by which glucose and oxygen become ATP. You are not supplementing for a benefit. You are replenishing a coenzyme your biology requires to function.
NAD+ exists in two forms — NAD+ (oxidised) and NADH (reduced). The ratio between these two forms is a direct readout of your cellular metabolic state. As NAD+ is consumed producing NADH in the electron transport chain, it must be continuously regenerated. The NAD+/NADH ratio in healthy, young mitochondria sits around 700:1. In aged, metabolically impaired tissue, this ratio collapses. Energy production drops. DNA repair stalls. Sirtuin activity halts.
By the age of 50, NAD+ levels in most tissues have declined by 40–50% compared to levels at age 20. This is not a coincidence — it is one of the foundational mechanisms of biological aging. The decline of NAD+ maps directly to the decline of mitochondrial function, sirtuin-mediated longevity signalling, and PARP-mediated DNA repair.
