Key insights into the ‘master’ antioxidant:
Glutathione (or GSH in its reduced form) is a tri-peptide (cysteine, glycine, and glutamic acid) found in most cells. GSH has many roles, including:
- Recycles other antioxidants, such as vitamins C and E
- A prime intracellular position to neutralise free radicals, which can build up in cells and cause damage
- Support healthy liver function – the highest concentrations of glutathione are found in the liver and kidneys, which are responsible for the removal of toxic components
- Immune-supportive via the proper function of white blood cells, including T cell lymphocytes and the multiplication of lymphocytes
- Transportation of mercury out of cells and the brain
- Regulation of cellular proliferation and apoptosis
- Vital to mitochondrial function and maintenance of mitochondrial DNA
It is proposed that disturbances to GSH homeostasis are implicated in the aetiology and/or progression of a number of diseases. Low levels can be caused by a range of factors including inadequate intake of glutathione/precursors, increased demand (e.g. toxin load, inflammation) and suppression of glutathione formation.
Christine Gozlan
B.H.Sc. Naturopathy
Dip. Herbal medicine
Dip. Nutrition |
